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In a really latest examine, persistent administration of nicotine to mice (1 mg/kg every 3 days for a 60-day period) enhanced brain metastasis by skewing the polarity of M2 microglia, which increases metastatic tumour development [50]. Assuming that a traditional cigarette incorporates 0.172–1.702 mg of nicotine [51], the daily nicotine dose administered to those animals corresponds to 40–400 cigarettes for a 70 kg-adult, which is a dose of an especially heavy smoker. We would argue that further research with chronic administration of low doses of nicotine are required to clearly evaluate its impression on carcinogenicity.
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